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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1961
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: No specific test guideline was reported; however, a scientifically defensible approach was used to conduct the study.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1961
Report date:
1961

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The LD50 was determinated by intraperitoneal application of calcium acetate to inbred female mice (AGNES-BLUHM strain).
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Calcium di(acetate)
EC Number:
200-540-9
EC Name:
Calcium di(acetate)
Cas Number:
62-54-4
Molecular formula:
C2H4O2.1/2Ca
IUPAC Name:
calcium diacetate
Details on test material:
- Name of test material (as cited in study report): Calcium acetate
- Substance type: discrete
- Physical state: solid

Test animals

Species:
mouse
Strain:
other: Agnes-Bluhm
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
No data
No. of animals per sex per dose:
83 female mice
Control animals:
not specified

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
74.5 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

The result of the assay performed in 83 mice was: LD50 = 74.5 mg/kg bw.

Applicant's summary and conclusion

Conclusions:
The (48h) LD50 was 74.5 mg/kg bw.
Executive summary:

The result of calcium acetate LD50 assay was 74.5 mg/kg bw. The test was performed in 83 inbred female mice (Agnes-Bluhm strain) and the observation time was 48 hours.