Registration Dossier
Registration Dossier
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EC number: 204-614-1 | CAS number: 123-28-4
Endpoint summary
Administrative data
Description of key information
Additional information
- Danio rerio LC50(96h) > 71 mg/L (with a structural analogue > 100 mg/L)
- Daphnia magna EC50(24h) = 11 mg/L (with a structural analogue = 780 mg/L)
- Scenedesmus subspicatus EC50(72h) = 33.9 mg/L (with a structural analogue = 60 mg/L)
Read across justification:
In support of the available studies, experimental data from an analogue substance were considered. The analogue substance (EC 211 -750 -5) only differs in the lenght of its alkyl side chain (C18H37 instead of C12H25). According to REACh Annex XI, paragraph 1.5 "Grouping of substances and read across approach", similarities may be based on (1) a common functional group and (2) a common precursor and/or the likelihood of common breakdown products via physical and biological processes, which result in structurally similar chemicals. For the analogue substance (EC 211 -750 -5) these criteria are definitely fulfilled and therefore, a supporting read across seems appropriate. For further details please confer to Annex 1 of the chemical safety report.
No toxic effects occur at the range of water solubility.
- The test substance exhibits a very low water solubility (<1 mg/L). Therefore, bioavailability to aquatic organisms is strongly limited.
- All available acute tests for the test substance markedly show that toxic effects only occur far above the limit of water solubility.
- Activated sludge was not inhibited by the test substance (nor the structural analogue): IC50 > 100 mg/L.
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