Registration Dossier
Registration Dossier
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EC number: 205-598-9 | CAS number: 143-29-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
- Limit test:
- no
Test material
- Reference substance name:
- Bis(2-(2-butoxyethoxy)ethoxy)methane
- EC Number:
- 205-598-9
- EC Name:
- Bis(2-(2-butoxyethoxy)ethoxy)methane
- Cas Number:
- 143-29-3
- Molecular formula:
- C17H36O6
- IUPAC Name:
- 5,8,11,13,16,19-hexaoxatricosane
- Details on test material:
- - Name of test material (as cited in study report): Hexaoxatricosane (TP-90B Rubber Chemical)
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Italy S.r.l., San Pietro al Natisone, Italy
- Age at study initiation: 6-8 weeks
- Weight at study initiation: 176-200 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg
- Doses:
- 550, 2000 mg/kg bw
- No. of animals per sex per dose:
- 2000 mg/kg: 5 females
330 mg/kg: 1 female - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Immediately following dosing, 30 minutes, 2 hours, 4 hours, and daily thereafter for a total of 14 days.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- 1 animal died at 2000 mg/kg bw approximately one hour after dosing.
- Clinical signs:
- other: Animal 1 exhibited convulsions approximately 5 minutes following dosing. A degree of recovery soon occurred although the animal was lethargic 30 minutes after dosing and remained so throughout the first day. In addition, lacrimation was noted approximate
- Gross pathology:
- No abnormalities were observed in any animal at the necropsy examination performed at the end of the observation period or in the early decedent animal.
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
