Ethylamine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Acceptable publication but only limited data is given.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

1954

Reference 2

Reference Type:

publication

Title:

The Toxicity of Allylamines

Author:

Hine C. et al.

Year:

1960

Bibliographic source:

Arch. Env. Health Vol. 1, 1960, 343-352

Reference 3

Reference Type:

review article or handbook

Title:

Aliphatic and Alicyclic Amines

Author:

Benya T.J. et al.

Year:

1994

Bibliographic source:

Patty's Industrial Hygiene and Toxicology, Vol. 2, Part B, Chapter 17

Materials and methods

Principles of method if other than guideline:

- Principle of the test: According to Draize, J.H. et al.: J. Pharmacol. and Exper. Therap. 82:377, 1944
- Short description of test conditions: Penetration of rabbit skin was estimated by a technique closely skin to the one-day cuff method of Draize and associates, using groups of four male. The fur was removed from the entire trunk by clipping, and the dose was retained beneath an impervious plastic film. The animals were immobilized during the 24 hour contact period, after which the film was removed and the rabbits were caged for the subsequent 14 day observation period.

GLP compliance:

no

Remarks:

predating GLP

Test material

Test material information

Constituent 1

Reference substance name:

Ethylamine

EC Number:

200-834-7

EC Name:

Ethylamine

Cas Number:

75-04-7

Molecular formula:

C2H5NH2

IUPAC Name:

ethanamine

Details on test material:

- Name of test material (as cited in study report): Ethylamine
- Analytical purity: no data

Test animals

Species:

rabbit

Strain:

New Zealand White

Remarks:

giant

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 2.5 to 3.5 kg

Administration / exposure

Type of coverage:

occlusive

Vehicle:

not specified

Duration of exposure:

24 h

Doses:

no data

No. of animals per sex per dose:

4

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

265 mg/kg bw

95% CL:

201 - 395

Remarks on result:

other: original value LD50 = 0.39 ml/kg

Mortality:

no data

Clinical signs:

no data

Body weight:

no data

Gross pathology:

no data

Applicant's summary and conclusion

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

The mean lethal dose of the test substance after single dermal application for 24 hours was found to be 265 mg/kg bw in rabbits.

Executive summary:

Penetration of rabbit skin with the test article was estimated by a technique closely skin to the one-day cuff method of Draize and associates (Draize et al. 1944), using groups of four male New Zealand giant albino rabbits. The fur was removed from the entire trunk by clipping, and the dose was retained beneath an impervious plastic film. The animals were immobilized during the 24 hour contact period, after which the film was removed and the rabbits were caged for the subsequent 14 day observation period. Based on the study results a LD50 of 265 mg/kg/bw was calculated.