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EC number: 200-834-7
CAS number: 75-04-7
Penetration of rabbit skin with the test article was estimated by a
technique closely skin to the one-day cuff method of Draize and
associates (Draize et al. 1944), using groups of four male New Zealand
giant albino rabbits. The fur was removed from the entire trunk by
clipping, and the dose was retained beneath an impervious plastic film.
The animals were immobilized during the 24 hour contact period, after
which the film was removed and the rabbits were caged for the subsequent
14 day observation period. Based on the study results a LD50 of 265
mg/kg/bw was calculated.
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