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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other:
Remarks:
Acceptable publication but only limited data is given.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1954
Reference Type:
publication
Title:
Unnamed
Year:
1991
Reference Type:
publication
Title:
The Toxicity of Allylamines
Author:
Hine C. et al.
Year:
1960
Bibliographic source:
Arch. Env. Health Vol. 1, 1960, 343-352
Reference Type:
review article or handbook
Title:
Aliphatic and Alicyclic Amines
Author:
Benya T.J. et al.
Year:
1994
Bibliographic source:
Patty's Industrial Hygiene and Toxicology, Vol. 2, Part B, Chapter 17

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Principle of test:
Single oral dose toxicity is estimated by the gastric intubation of groups of five non-fasted Carworth-Wistar rats, weighing 90 to 120 grams and maintained from time of weaning on Rockland rat diet, complete. The most probable LD50 value and its fiducial range were estimated by the method of Thompson.
GLP compliance:
no
Remarks:
predating GLP
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylamine
EC Number:
200-834-7
EC Name:
Ethylamine
Cas Number:
75-04-7
Molecular formula:
C2H5NH2
IUPAC Name:
ethanamine
Details on test material:
- Name of test material (as cited in study report): Ethylamine
- Analytical purity: no data
Specific details on test material used for the study:
FORM AS APPLIED IN THE TEST: Aqueous solution

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 90 to 120 grams
- Diet: Rockland rat diet

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED: 1 to 10 mL

Doses:
No data; dosages were in a logartitmic series
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
400 mg/kg bw
Based on:
test mat.
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The mean lethal dose of the test substance after single oral administration was found to be 400 mg/kg bw in rats.
Executive summary:

The test article was administered to a group of 5 non-fasted Carworth-Wistar rats by intubation of dosages in a logartithmic series. After 14 days of observation the single dose oral toxicity was calculated to be 400 mg/kg bw.

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