Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 244-214-4 | CAS number: 21109-95-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Testing with a corrosive substance is not allowed due to animal welfare and in accordance with section 8.3, column 2, Annex VII of regulation (EC) 1907/2006). Since barium sulfide was tested to be corrosive to skin with a pH value of 13.0 (1% solution), testing is not justified.
Nevertheless, the sensitisation potentialmay reasonably be considered by the availability of barium cations and sulfide anions.
Barium:
Upon dissolution in water and/or physiological media, dissociation to barium sulfide to release Ba2+ions may initially be expected.
However, based on the established fact that barium ions may form poorly soluble species for example with physiologically present carbonate ions, the bioaccessibility/bioavailability may vary between different physiological conditions. Notwithstanding this limitation, it is considered justified to read-across from available data either on barium hydroxide (similar water solubility) and/or barium chloride (higher water solubility), the latter representing a conservative approach). In this context, the water solubility of a substance is used as a first approximation of bioavailability:
- barium chloride is highly water soluble with ca. 375 g/L at 20°C/pH ca. 6.5 (510.4 g/L at pH 1.5)
- barium hydroxide is also highly water soluble (37.4 g/L at 20°C/pH > 13).
In comparison, the water solubility of barium sulfide is given with 73.5 g/L at 20°C (pH 13.7; saturated solution).
Sulfides: Sulfides may be seen as ions endogenously occurring under physiological conditions, so that their role in normal human metabolism suggests that a sensitisation potential does not necessarily need to be expected.
In addition it could be stated that long time experience in handling with barium substances and sulfides does not show any sensitising effects in humans.
Summarising that the LLNA study conducted with barium dichloride dihydrate causes no sensitising effects to skin and read across to soluble barium substances (i.e., barium dichloride) is justified, a sensitisation potential for barium sulfide can safely be excluded.
Migrated from Short description of key information:
No data are available on skin sensitisation of barium sulfide. As barium sulfide is classified for skin corrosivity and has a pH value 13.0 (1% solution) no testing needs to be initiated. However, testing with barium dichloride dihydrate was conducted and study result indicates that the test item is considered not to be skin sensitising.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the outcome of the sensitisation study according OECD 429 conducted with barium dichloride dihydrate and under consideration of read-across (see discussion) it can be concluded that barium sulfide does not have a sensitisation potential and therefore must not be classified and labelled according to Directive 67/548/EEC and Regulation (EC) 1272/2008.
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