Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Information from TSCA 8e section; no full report in hand but result has impact on hazardous properties and classification and labelling of test material

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1995
Report Date:
1995

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
A mixture of approx. 50:50 1-chloro-2-butene and 3-chloro-1-butene were tested.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
16.3 mg/L air (analytical)
Other findings:
- Potential target organs: CNS

Any other information on results incl. tables

2/6 animals died in the 2990 ppm group, 3/6 in the 4410 ppm and 5/6 in the 6290 ppm group. (LC50 ca. 4410 ppm) Clinical signs: Impairment of startle response from 359 ppm. At 2990 and 4410 ppm abnormal gait, impaired mobility, changes in arousal, hunched posture, irregular respiration. Approximate LC50 in mg/l: 4410 ppm * 90.55/24.45 * 1000 = 16.3 mg/l

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Remarks:
Migrated information
Conclusions:
2/6 animals died in the 2990 ppm group, 3/6 in the 4410 ppm and 5/6 in the 6290 ppm group. (LC50 ca. 4410 ppm)
Clinical signs: Impairment of startle response from 359 ppm. At 2990 and 4410 ppm abnormal gait, impaired mobility, changes in arousal, hunched posture, irregular respiration. Approximate LC50 in mg/l: 4410 ppm * 90.55/24.45 * 1000 = 16.3 mg/l