Registration Dossier
Registration Dossier
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EC number: 210-765-4 | CAS number: 623-03-0
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Synthesis and Antiflammatory Evaluation of Substituted Isophthalonitriles, Trimesonitriles, Benzonitriles, and Terephthalonitriles
- Author:
- Heilmann, W.P., Battershell, R.D., et al.
- Year:
- 1 978
- Bibliographic source:
- Journal of Medicinical Chemistry, Vol. 21, No. 9
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- carrageenan-induced pedal edema assay
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- 4-chlorobenzonitrile
- EC Number:
- 210-765-4
- EC Name:
- 4-chlorobenzonitrile
- Cas Number:
- 623-03-0
- Molecular formula:
- C7H4ClN
- IUPAC Name:
- 4-chlorobenzonitrile
- Reference substance name:
- 4-Chlorobenzonitril
- IUPAC Name:
- 4-Chlorobenzonitril
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 0.25%
- Analytical verification of doses or concentrations:
- not specified
- Frequency of treatment:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
200 mg/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
- Details on results:
- Carrageenan injected into the plantar tissue of the hind paw of the test animals produces an edematous condition with simulates, in parts, the inflammatory process found in human arthritis. The subsequent oral application of 200 mg/kg 4-Chlorobenzonitrile led to an 30% reduction of the edema.The LD50 was reported to be > 300 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- Oral application of 200 mg/kg bw 4-Chlorobenzonitrile has an anti-inflammatory effect in the carrageenan-induced pedal edema assay in rat. An LD50 of > 300 mg/kg bw was reported.
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