Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

DIDP is a non-genotoxic agent.


Short description of key information:
DIDP is not mutagenic in vitro in bacterial mutation assays (with and without metabolic activation) and is negative in a mouse lymphoma assay (Zeiger et al., 1982; 1985; Hazleton Biotechnologies Company, 1986; Barber et al., 2000). DIDP is not clastogenic in a mouse micronucleus assay in vivo (Hazleton Washington, 1994; McKee et al., 2000).

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Substances known to be mutagenic to man (Category 1) or substances which should be regarded as if they are mutagenic to man (Category 2) based on sufficient animal studies or other relevant information also defines the criterion for T. DIDP is not mutagenic in in vitro bacterial mutation assays (with and without metabolic activation) and is negative in a mouse lymphoma assay (Zeiger et al., 1982; 1985; Hazleton Biotechnologies Company, 1986; Barber et al., 2000). DIDP is not clastogenic in a mouse micronucleus assay in vivo (Hazelton Washington, 1994; McKee et al., 2000). Therefore, DIDP is a non-genotoxic agent which does not meet the criterion for T based on mutagenicity.