Registration Dossier
Registration Dossier
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EC number: 271-090-9 | CAS number: 68515-48-0
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
In accordance with REACH Chapter R.7C Endpoint Specific Guidance, specifically R.7.11.6.3 Testing Strategy (Table R.7.11-2), data to characterize toxicity to terrestrial arthropods is waived for the following reasons. Di-isononyl phthalate ester (DINP) is ready biodegradable, consequently it is considered to degrade rapidly in the environment and not persist. DINP does not cause acute or chronic aquatic toxicity at its maximum water solubility, consequently it does not pose an acute or chronic aquatic hazard, and it is not possible to derive NOEC or PNEC values needed for quantitative risk assessment. However, it is possible to qualitatively conclude based on low solubility and available effects test data that DINP is not harmful to aquatic organisms. Acute and chronic toxicity data for soil macro-organisms, earthworms, also show that DINP does not cause effects at high soil loading rates. Therefore, based on these considerations, additional short and long-term toxicity testing for soil organisms is not needed.
LITERATURE RELATED TO DINP ENDOCRINE DISRUPTION POTENTIAL IN TERRESTRIAL ARTHROPODS PUBLISHED BETWEEN 2014 TO 2022:
A literature search allowed identifying two papers conducting tests of potential interest regarding the ecotoxicological effects of DINP in terrrestrial arthropods. However, after assessment it was concluded that all of them present significant reporting omissions or methodological flaws, rendering them not useful for regulatory assessment (Klimisch 3). For transparency, the RSS for those papers are included in this update (Zhang 2020 and Zhang 2021).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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