Registration Dossier
Registration Dossier
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EC number: 271-090-9 | CAS number: 68515-48-0
Toxicity to other aquatic organisms
Administrative data
Link to relevant study record(s)
Description of key information
DINP does not show any toxicity up to 858 mg/kg sediment (d.w.) in a test measuring the embryo development of moor frogs (Rana arvalis).
Additional information
The effects of DINP in a long-term toxicity study on the moor frog (Rana arvalis), a vertebrate, was evaluated by Solyomet al. (2001) in a natural sediment. The authors assessed egg hatchability followed by tadpole survival and growth over a 35-day exposure period. DINP at a measured concentration of 858 mg/kg sediment (dry weight) did not demonstrate a significant effect on frog egg hatching success following a 21-day exposure and tadpole survival and growth following a 35-day exposure. The 21- and 35-day NOEC values were each 858 mg/kg sediment (d.w.), which was the highest concentration tested.
LITERATURE RELATED TO DINP ENDOCRINE DISRUPTION POTENTIAL IN AQUATIC ORGANISMS PUBLISHED BETWEEN 2014 TO 2022:
A literature search allowed identifying two papers conducting tests of potential interest regarding the ecotoxicological effects of DINP in aquatic organisms other than fish. However, after assessment it was concluded that both present reporting omissions that justify a Klimisch score of 4. For transparency, the RSS for those papers are included in this update (Routti 2021 and Cocci 2017).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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