Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Additional information
Short description of key information:
No valid data available.

Effects on developmental toxicity

Description of key information
See discussion section.
Additional information

In NTP TR 275 a summary is given of reproductive toxicity studies (page 18):

Malformations and high rates of embryo mortality occurred when chick embryos were administered 2-chloroethanol at doses of 50 or 100 mg/kg (egg weight) at 0 or 96 hours of incubation (Verrett, 1974).

Fetotoxicity and maternal toxicity were produced when the compound was administered by gavage to pregnant Swiss CD-1 mice on days 4-12 of gestation (RTI, 1983a).

No effect on the mother or offspring occurred when 2-chloroethanol was administered in drinking water to Swiss CD-1 mice on days 6-16 of gestation. No teratogenic effects were noted in New Zealand white rabbits administered 2-chloroethanol intravenously at doses (36 mg/kg per day) that produced significant levels of fetotoxicity or maternal toxicity (RTI, 1983b).

Justification for classification or non-classification

Not classified. No valid data on fertility available. In developmental studies effects were only observed at maternal toxic levels.

Additional information