Registration Dossier
Registration Dossier
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EC number: 203-459-7 | CAS number: 107-07-3
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- other: Secondary reference IUCLID4
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Allavena A.
- Year:
- 1 991
- Bibliographic source:
- Pharmacology and Toxicology, 69 (Suppl. 2), 21
- Title:
- No information
- Author:
- Allavena, A. et al.
- Year:
- 1 992
- Bibliographic source:
- Teratogen. Carcinogen. Mutagen. 12, 31-41
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 2-chloroethanol
- EC Number:
- 203-459-7
- EC Name:
- 2-chloroethanol
- Cas Number:
- 107-07-3
- Molecular formula:
- C2H5ClO
- IUPAC Name:
- 2-chloroethan-1-ol
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- einmalig oder zweimal im Abstand von 24 Stunden
Doses / concentrations
- Remarks:
- Doses / Concentrations:
45.5 mg/kg (1/2 LD50)
Basis:
Results and discussion
Test results
- Sex:
- male
Any other information on results incl. tables
RS-Freetext:
negativ;
Nach einmaliger bzw. zweimaliger Gabe von
Ethylenchlorhydrin an maennl. Sprague Dawley Ratten war
die Zahl der Micronuclei in Hepatocyten und in
polychromat. Erythrocyten 20 bzw. 68 Std. nach einmaliger
Applikation und 6 Std. nach zweimaliger Applikation nicht
erhoeht.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
