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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
other: Secondary reference IUCLID4
Adequacy of study:
other information
Reliability:
4 (not assignable)

Data source

Referenceopen allclose all

Title:
No information
Author:
Allavena A.
Year:
1991
Bibliographic source:
Pharmacology and Toxicology, 69 (Suppl. 2), 21
Title:
No information
Author:
Allavena, A. et al.
Year:
1992
Bibliographic source:
Teratogen. Carcinogen. Mutagen. 12, 31-41

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
not specified
Type of assay:
micronucleus assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Duration of treatment / exposure:
einmalig oder zweimal im Abstand von 24 Stunden
Doses / concentrations
Remarks:
Doses / Concentrations:
45.5 mg/kg (1/2 LD50)
Basis:

Results and discussion

Test results
Sex:
male

Any other information on results incl. tables

RS-Freetext:
negativ;
Nach einmaliger bzw. zweimaliger Gabe von
Ethylenchlorhydrin an maennl. Sprague Dawley Ratten war 
die Zahl der Micronuclei in Hepatocyten und in 
polychromat. Erythrocyten 20 bzw. 68 Std. nach einmaliger
Applikation und 6 Std. nach zweimaliger Applikation nicht
erhoeht.

Applicant's summary and conclusion