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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Type of information:
other: Secondary reference IUCLID4
Adequacy of study:
other information
Reliability:
4 (not assignable)

Data source

Reference
Title:
No information
Author:
Minden H et al.
Year:
1969
Bibliographic source:
Dtsch. Gesundheitsw. 24 (40), 1894-1897

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intravenous
Duration of treatment / exposure:
9 Tage
Frequency of treatment:
5 Applikationen im Abstand von je 2 Tagen
Doses / concentrations
Remarks:
Doses / Concentrations:
30 mg/kg
Control animals:
yes, concurrent vehicle
Details on study design:
Post-exposure period: bis 28 Tage nach Versuchsbeginn

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
Bei biochemischen Untersuchungen nach 2 bzw. 4 Wochen 
wurde eine signifikante Erhoehung der
Glucose-6-Phosphat-Dehydrogenase, der
Isocitronensaeuredehydrogenase, der Sorbit-Dehydrogenase,
der GOT und des Gesamtcholesterols in der Leber
festgestellt. Die Aktivitaet der alkal. Phosphatase war
reduziert. Die Aktivitaet der Glutaminsaeure-Dehydrogenase
war nur nach 2 Wochen erhoeht, auch das Lebergewicht war 
nur nach 2 Wochen erhoeht, nach 4 Wochen wurden wieder
normale Werte bestimmt. Dies deutet nach Angaben der 
Autoren darauf hin, dass die beobachteten Veraenderungen
reversibel waren.

Applicant's summary and conclusion