Registration Dossier
Registration Dossier
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EC number: 203-459-7 | CAS number: 107-07-3
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Type of information:
- other: Secondary reference IUCLID4
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
Data source
Reference
- Title:
- No information
- Author:
- NTP
- Year:
- 1 985
- Bibliographic source:
- : "Toxicology and Carcinogenesis Studies of|2-Chloroethanol in F344/N Rats and Swiss CD-1 Mice", NIH|Publication No.86-2531, NTP TR 275
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-chloroethanol
- EC Number:
- 203-459-7
- EC Name:
- 2-chloroethanol
- Cas Number:
- 107-07-3
- Molecular formula:
- C2H5ClO
- IUPAC Name:
- 2-chloroethan-1-ol
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 14 Tage
- Frequency of treatment:
- taeglich
Doses / concentrations
- Remarks:
- Doses / Concentrations:
114/147, 172/222, 226/313, 339/451, 442/611 mg/kg (maennl./weibl.; 20, 30, 40, 60, 80 mg/Tier)
Basis:
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Post-exposure period: keine
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Ein maennliches Tier der hoechsten Dosisgruppe und zwei
weibliche Tiere der 60 mg Gruppe starben waehrend der
Studie. Die Koerpergewichtsentwicklung war im Vergleich zur
Kontrolle unveraendert.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
