Registration Dossier

Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
repeated dose toxicity: dermal
Type of information:
other: Secondary reference IUCLID4
Adequacy of study:
other information
Reliability:
4 (not assignable)

Data source

Reference
Title:
No information
Author:
NTP
Year:
1985
Bibliographic source:
: "Toxicology and Carcinogenesis Studies of|2-Chloroethanol in F344/N Rats and Swiss CD-1 Mice", NIH|Publication No.86-2531, NTP TR 275

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
14 Tage
Frequency of treatment:
taeglich
Doses / concentrations
Remarks:
Doses / Concentrations:
114/147, 172/222, 226/313, 339/451, 442/611 mg/kg (maennl./weibl.; 20, 30, 40, 60, 80 mg/Tier)
Basis:

Control animals:
yes, concurrent vehicle
Details on study design:
Post-exposure period: keine

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
Ein maennliches Tier der hoechsten Dosisgruppe und zwei
weibliche Tiere der 60 mg Gruppe starben waehrend der
Studie. Die Koerpergewichtsentwicklung war im Vergleich zur
Kontrolle unveraendert.

Applicant's summary and conclusion