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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
repeated dose toxicity: inhalation
Type of information:
other: Secondary reference IUCLID4
Adequacy of study:
other information
Reliability:
4 (not assignable)

Data source

Reference
Title:
No information
Author:
Strusevich E.A. et al.
Year:
1972
Bibliographic source:
: Gig. Tr. Prof. Zabol., 11, 42-43,|(1972).|Zitiert in: DIMDI-Toxall, ND: CA/078/053642C, (1973)

Materials and methods

Principles of method if other than guideline:
Method: other: no data
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
4 Monate
Frequency of treatment:
kontinuierlich
Doses / concentrations
Remarks:
Doses / Concentrations:
0.001; 0.01 mg/l
Basis:

Control animals:
other: no data specified
Details on study design:
Post-exposure period: ja (keine genaueren Angaben)

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
Die russ. Studie liegt nur als Abstract vor.
In beiden Dosierungen wurde ein Ansteigen des 
Blutlecithin- und Blutcholesterolwertes beschrieben, die 
auf Stoerungen des Leber-Lipid-Metabolismus hindeuten. Bei
den Tieren der niederen Dosierung konnte 2 Wochen nach
Behandlungsende kein veraenderter Lipidmetabolismus
festgestellt werden. Keine weiteren Angaben liegen vor.

Applicant's summary and conclusion