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EC number: 203-459-7 | CAS number: 107-07-3
Table 1.: Summary of ocular lesions mean of 6 animals per group
Days after application
This paper reports on the effect of pure 2-chloroethanol, and various dilutions of this material, on several of the tissue types with which a tracheotomy tube might come into contact in a patient. It was found that pure 2-chloroethanol is quite destructive to most of the tissues, including ophthalmic, mucosal, muscular, and subcutaneous tissues; however, on dilution, the toxicity potential decreased sharply. Dilutions of 1:10 were still toxic, but in most cases, dilutions of 1:100 were practically innocuous. A cell culture evaluation correlated almost perfectly with in vivo techniques.
The average score for all animals for eye irritation for 24-48-72 hour is 0.27 for cornea, 1.9 for Iris, 1.9 for redness and 1.5 for chemosis. Only the undiluted 2-chloroethanol caused a transient clouding of the cornea, and no further damage to this structure was noted even when checked with fluorescein sodium solution after 24 hours. There was irritation of the iris which was manifested primarily in the form of inflammation. It should be noted that 1: 5 dilution of 2-chloroethanol caused only a transient inflammation. There was excessive swelling and obvious reddening of the conjunctiva at the 24-hour observation period, and the condition worsened up to and including the 72-hour period. Recovery was complete in approximately 1 week.
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