Registration Dossier

Physical & Chemical properties

Melting point / freezing point

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From October 2009 to February 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
capillary method
Key result
Melting / freezing pt.:
321.72 K
Atm. press.:
102.1 kPa
Sublimation:
no
Remarks on result:
other: S.D. = ± 0.21

 

Sample

Initial value ofmelting point, K

Final value of

melting point, K

The difference between the initial and the final value of melting point (absolute value), K

Atmospheric pressure, kPa

1

321.85

321.95

|0.1|

102.1

2

321.45

321.65

|0.2|

102.1

3

321.25

321.55

|0.3|

102.1

Average values

± standard

deviation, K

321.52 ± 0.31

321.72 ± 0.21

102.1

Conclusions:
The average value of the melting point of the test substance was determined to be 321.72 ± 0.21 K under atmospheric pressure of 102.1 kPa.
Executive summary:

A study was conducted to determine the melting point of the test substance according to EU Method A.1. using a capillary tube in a heated metal block. A dried finely ground sample was placed in a capillary tube. The measurements were performed in three parallel tubes using BŐCHI Melting Point 545 apparatus. The measurements were performed in the temperature range of 311.15 K – 326.15 K with a temperature gradient of 0.5 K/min. Initially, the temperature was increased at a rate of 3 K/min. The average value of the melting point was determined to be 321.72 ± 0.21 K under atmospheric pressure (102.1 kPa) (Olszewska, 2010).

Description of key information

The melting point was determined according to EU Method A.1 (Olszewska, 2010).

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
48.57 °C

Additional information