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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
other: Data sharing dispute
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: limitations with regard to the test method and/or reporting but contributing to a weight of e vidence approach

Data source

Reference
Reference Type:
publication
Title:
The toxicity of sulfur hexafluoride.
Author:
Lester D., Greenberg L.A.
Year:
1950
Bibliographic source:
Arch. Ind. Hyg. Occup. Med. 2:348-349

Materials and methods

Principles of method if other than guideline:
Assessment of acute toxicity. No details on the test protocol are given.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sulphur hexafluoride
EC Number:
219-854-2
EC Name:
Sulphur hexafluoride
Cas Number:
2551-62-4
Molecular formula:
F6S
IUPAC Name:
sulphur hexafluoride
Test material form:
gas
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Adult white rats (sex and species not specified) where exposed to various concentration of sulfur hexafluoride in a glass chamber. The exposure conditions were not specified. Six rats were exposed to 17% SF6 for 18 hrs. Three and two animals were exposed to 80% of the test substance for 2 and 23 hours, respectively.
Analytical verification of test atmosphere concentrations:
not specified
Concentrations:
Adult white rats (sex and species not specified) where exposed to various concentration of sulfur hexafluoride in a glass chamber. The exposure conditions were not specified. Six rats were exposed to 17% SF6 for 18 hrs. Three and two animals were exposed to 80% of the test substance for 2 and 23 hours, respectively.
No. of animals per sex per dose:
Adult white rats (sex and species not specified) where exposed to various concentration of sulfur hexafluoride in a glass chamber. The exposure conditions were not specified. Six rats were exposed to 17% SF6 for 18 hrs. Three and two animals were exposed to 80% of the test substance for 2 and 23 hours, respectively.
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC0
Effect level:
> 800 000 ppm
Exp. duration:
23 h
Mortality:
No mortality occurred.
Clinical signs:
other: Six rats were exposed to 17% SF6 for 18 hrs. Three and two animals were exposed to 80% of the test substance for 2 and 23 hours, respectively. All these animals did not show any clinical sign of irritation or toxic effect during and at the end of the expo
Body weight:
No effects.
Gross pathology:
No effects.
Other findings:
According to the authors, about 50 other rats were exposed to SF6 80% and O2 20% for periods of 16 to 24 hours without any indication of adverse effects.

Applicant's summary and conclusion