Tris(2-chloro-1-methylethyl) phosphate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions.

Data source

Reference

Reference Type:

publication

Title:

TRIS(2-CHLORO-1-METHYLETHYL) PHOSPHATE (TCPP)

Author:

Ireland (lead) and United Kingdom

Year:

2008

Bibliographic source:

European Union Risk Assessment Report

Materials and methods

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tris(2-chloro-1-methylethyl) phosphate

EC Number:

237-158-7

EC Name:

Tris(2-chloro-1-methylethyl) phosphate

Cas Number:

13674-84-5

Molecular formula:

C9H18Cl3O4P

IUPAC Name:

tris(2-chloro-1-methylethyl) phosphate

Details on test material:

There are differences in the isomer content from each supplier,but these are not important given that the properties of the isomers are expected to be very similar.
Purity
A typical purity(total of the four isomers)is>97.9%.All testing described in this report is for the commercial product.
Impurities
The impurity profile of the commercial product TCPP is specific to individual manufacturers. It is not likely that the impurities will have had particular influence on any of the results obtained.
Additives
No additives are used.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

other: no data

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

4 h

Concentrations:

7.19 mg/L

No. of animals per sex per dose:

5 female and 5 male

Control animals:

not specified

Details on study design:

Duration of observation period following administration: 14 days
All rats were weighed immediately before dosing and on days 1 and 3 post exposure for the dose ranging finding study and on days 2, 3, 4, 7, 10 and 14 post exposure for the main study.
At the end of the study, all animals were subjected to a macroscopic post mortem exam.

Statistics:

no data

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 7 mg/L air

Exp. duration:

4 h

Mortality:

There were no deaths during the study.

Clinical signs:

other: No unusual clinical observations were recorded during the exposure period. No abnormalities were observed during the subsequent 14-day observation period.

Body weight:

There was no effect on body weight.

Gross pathology:

no data

Any other information on results incl. tables

There were no deaths during the study. No unusual clinical observations were recorded during the exposure period. All animals appeared slightly unkempt and had red staining around the snout and eyes immediately after dosing. No abnormalities were observed during the subsequent 14-day observation period. There was no effect on body weight. No abnormalities were observed at post mortem. The acute inhalation LC50 is taken to be greater than 7 mg/L from this study.