Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Toxicokinetics, metabolism and distribution: 
Absorption (oral): >=75%

Key value for chemical safety assessment

Additional information

In the in vivo oral study on absorption, distribution,and excretion of TCPP, there were indications of <100% absorption after oral administration when oral and i.v.dosing were compared. It is quite difficult to estimate the percent oral absorption. However, it appears from the available information that oral absorption is at least 75%, and may be slightly higher. Therefore, 80% oral absorption will be taken forward to risk characterisation. This study is taken forward in preference to other two studies, as it was more relevant to assume the oral bioavailability.