Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-158-7 | CAS number: 13674-84-5
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: acute oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: USA EPA proposed guideline for acute delayed neurotoxicity FR43(163):37362-37363,1978
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tris(2-chloro-1-methylethyl) phosphate
- EC Number:
- 237-158-7
- EC Name:
- Tris(2-chloro-1-methylethyl) phosphate
- Cas Number:
- 13674-84-5
- Molecular formula:
- C9H18Cl3O4P
- IUPAC Name:
- tris(2-chloro-1-methylethyl) phosphate
Constituent 1
Test animals
- Species:
- hen
- Strain:
- other: white leghorn hen
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- corn oil
- Duration of treatment / exposure:
- No data.
- Frequency of treatment:
- Two doses (10ml/kg each) were administered orally to hens 21 days apart.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10ml/kg
Basis:
no data
- No. of animals per sex per dose:
- 18 animals per dose
- Control animals:
- yes
- Details on study design:
- The study has positive and negative control
positive control: TOCP
negative control: corn oil
Results and discussion
Results of examinations
- Details on results:
- No inhibit either plasma and cholinesterase or brain neurotoxic esterase 24 hours after dosing.
No motor impairment observed to compare with that seen in TOCP group.
Applicant's summary and conclusion
- Conclusions:
- No evidence of delayed neurotoxicity was noted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
