Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 237-158-7 | CAS number: 13674-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: acute oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: USA EPA proposed guideline for acute delayed neurotoxicity FR43(163):37362-37363,1978
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tris(2-chloro-1-methylethyl) phosphate
- EC Number:
- 237-158-7
- EC Name:
- Tris(2-chloro-1-methylethyl) phosphate
- Cas Number:
- 13674-84-5
- Molecular formula:
- C9H18Cl3O4P
- IUPAC Name:
- tris(2-chloro-1-methylethyl) phosphate
Constituent 1
Test animals
- Species:
- hen
- Strain:
- other: white leghorn hen
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- corn oil
- Duration of treatment / exposure:
- No data.
- Frequency of treatment:
- Two doses (10ml/kg each) were administered orally to hens 21 days apart.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10ml/kg
Basis:
no data
- No. of animals per sex per dose:
- 18 animals per dose
- Control animals:
- yes
- Details on study design:
- The study has positive and negative control
positive control: TOCP
negative control: corn oil
Results and discussion
Results of examinations
- Details on results:
- No inhibit either plasma and cholinesterase or brain neurotoxic esterase 24 hours after dosing.
No motor impairment observed to compare with that seen in TOCP group.
Applicant's summary and conclusion
- Conclusions:
- No evidence of delayed neurotoxicity was noted.
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