Registration Dossier
Registration Dossier
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EC number: 209-711-2 | CAS number: 591-27-5
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18.05.2012 to 07.06.2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Justification for type of information:
- DATA IS FROM STUDY REPORT
- Qualifier:
- according to guideline
- Guideline:
- other: Gravimetric method
- Principles of method if other than guideline:
- Weight of the chemical substance (fat) to dissolve in Organic Solvent to form a homogeneous solution of the solute in the solvent
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Specific details on test material used for the study:
- - Name of test material: 3-aminophenol
- IUPAC name: 1-Hydroxy-3-amino-benzene
- Molecular weight: 109.127 g/mole
- Molecular formula: C6H7NO
- Smiles: c1c(cccc1O)N
- InChI: 1S/C6H7NO/c7-5-2-1-3-6(8)4-5/h1-4,8H,7H2
- Substance type: Organic
- Physical state: Solid Crystalline (white) - Medium:
- methanol
- Solubility:
- 115 000 mg/L
- Temp.:
- 35 °C
- Conclusions:
- Solublility of 3-aminophenol in methanol is found to be 115000 mg/L at 35°C
- Executive summary:
Solublility of 3-aminophenol in methanol is found to be 115000 mg/L at 35°C.
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18.05.2012 to 07.06.2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Justification for type of information:
- Data is from study report
- Qualifier:
- according to guideline
- Guideline:
- other: Gravimetric method
- Principles of method if other than guideline:
- Weight of the chemical substance (fat) to dissolve in Organic Solvent to form a homogeneous solution of the solute in the solvent
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Specific details on test material used for the study:
- - Name of test material: 3-aminophenol
- IUPAC name: 1-Hydroxy-3-amino-benzene
- Molecular weight: 109.127 g/mole
- Molecular formula: C6H7NO
- Smiles: c1c(cccc1O)N
- InChI: 1S/C6H7NO/c7-5-2-1-3-6(8)4-5/h1-4,8H,7H2
- Substance type: Organic
- Physical state: Solid Crystalline (white) - Medium:
- other: Petroleum Ether
- Temp.:
- 35 °C
- Remarks on result:
- other: Insoluble
- Conclusions:
- 3-aminophenol is found to be insoluble in petroleum ether at 35°C
- Executive summary:
Using the Soxhlet/Solvent extraction method, 3-aminophenol is found to be insoluble in petroleum ether at 35°C
Referenceopen allclose all
Description of key information
Gravimetric method was used to determine the solubility of the substance in organic solvent. The experimental value of solubility of 3-aminophenol in methanol aat 35°C was found to be 115000 mg/L.Using the Soxhlet/Solvent extraction method, 3-aminophenol is found to be insoluble in petroleum ether at 35°C
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 115 000 mg/L
Additional information
Gravimetric method was used to determine the solubility of the substance in organic solvent. The experimental value of solubility of 3-aminophenol in methanol aat 35°C was found to be 115000 mg/L. Using the Soxhlet/Solvent extraction method, 3-aminophenol is found to be insoluble in petroleum ether at 35°C.
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