Registration Dossier
Registration Dossier
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EC number: 249-109-7 | CAS number: 28629-66-5
Endpoint summary
Administrative data
Description of key information
The test material is not acutely toxic.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 200 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
Acute Oral Toxicity:
The oral LD50 was determined to be 3200 mg/kg in male rats (Gabriel, K.L., 1978). Sublethal effects of depression, lethargy, and semi-comatose to comatose states were observed. Survivors appeared normal after 7 days. Necropsy observations were unremarkable, no specific organ toxicity was evident. In accordance with EU CLP Regulation (EC) No. 1272/2008, classification is not required for acute oral toxicity based on the available data.
Acute Dermal Toxicity :
An LD50 of > 5000 mg/kg was identified via dermal application for male rabbits with an analog EC 224-235-5 (Bullock, CH et al, 1975). Severe erythema and edema noted at 24 hours. Necrotic-appearing areas of lung tissue observed in five rabbits. Further histology of the lungs revealed confluent bronchopneumonia or chronic interstitial pneumonia. In accordance with EU CLP Regulation (EC) No. 1272/2008, classification is not required for acute dermal toxicity, or specific organ toxicity after single dose, based on the available data.
Justification for classification or non-classification
In accordance with EU CLP (Regulation (EC) No. 1272/2008), classification of this substance is not required for acute toxicity.
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