Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report Date:
1981

Materials and methods

GLP compliance:
not specified
Test type:
acute toxic class method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
Test animals:
Wistar rats, males, 9 weeks old at the beginning of the test. Average weight at the beginning of the test: 169 g.
Tested in groups of 5 animals.
Conditions: 22 +/- 1.5°C; 12h light/dark cycle; humidity 60 +/- 5% .
Source: Winkelmann, Borchen.
Feed: Altromin R 1324 and tap water ad libitum.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
The test substance was administered unchanged by gavage.
The mixture was given once on the beginning of the test.
Doses:
0.5 ml/kg bw; 0.8 ml/kg bw; 0.9 ml/kg bw; 1.0 ml/kg bw; 1.2 ml/kg bw
No. of animals per sex per dose:
5 per sex per dose
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
0.84 mL/kg bw
Based on:
test mat.
Sex:
male
Dose descriptor:
LD50
Effect level:
1 050 mg/kg bw
Based on:
test mat.
Remarks on result:
other: calculated from density and volume.

Applicant's summary and conclusion

Conclusions:
The LD50 value for acute oral toxicity is 0.84 ml/kg bw in male Wistar rats.
The LD50 value for acute oral toxicity is 1050 mg/kg bw in male Wistar rats (the value is calculated based on the density)