Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-164-6 | CAS number: 7789-41-5
Endpoint summary
Administrative data
Description of key information
Semichronic Toxicity Study of Sodium Bromide in Rats
Key value for chemical safety assessment
Additional information
Read across from NaBr to CaBr2 is possible due to the full dissociation of both compounds in water. Na+ and Ca2+ are not toxic in the concentration ranges where Br- is toxic. Therefore only the Br- is responsible for the toxicity effects.
The repeated dose toxicity of sodium bromide was measured in several studies, and used as read across.
Observations in a 4-week oral study in female rats (Van Logten M.J.et al., 1973) and a 90-day oral study in male and female rats (Van Logten M.J.et al., 1974) demonstrated that sodium bromide caused behavioural changes, growth reduction, increased thyroid and adrenals weights, and a dose-related disturbance of the endocrine system. The NO(A)EL for rats was 300 ppm in feed or 15 mg (Br-)/kg bw/day (conversion done by the authors) from the 90-day oral study. The results of an additional 90-day repeat dose study with sodium bromide (Van Logten M.J.et al., 1976) did not show any evidence of cellular change, even in potential target tissues. Repeat dose studies in dogs were performed according to non-standard tests in which animals received 78 rising to 312 mg (Br-)/kg bw/day for 400 days (Rosenblum I., 1958). Signs of toxicity noted were stated as being comparable with signs noted in human after suffering bromide intoxication, and the study author states that dogs receiving 78 mg (Br-)/kg/day showed no mortalities and only minimal signs of toxicity. The lowest NO(A)EL from sub-chronic toxicity studies is 300 ppm in feed or 15 mg (Br-)/kg bw/day (conversion done by the authors) from the 90-day oral study in rats (Van Logten M.J.et al., 1974).
Justification for classification or non-classification
The results from the different repeated dose toxicity test do not justify classification of CaBr2 for repeated dose toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
