Registration Dossier
Registration Dossier
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EC number: 232-164-6 | CAS number: 7789-41-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
All twenty animals in the Test Group reacted to the Challenge application with Grades 1 to 3 in severity. A Grade 3 reaction was produced in 4/20 animals in the Test Group. Nine of the ten Naive Control animals reacted with a Grade 1 or 2 severity. Reactions in the Test Group which were stronger than the reactions seen in the Naive Control Group are considered sensitization responses. Therefore, the four animals in the Test Group which reacted with a Grade 3 level are considered sensitized.
Migrated from Short description of key information:
Guinea Pig Maximization Study with Calcium Bromide
Justification for classification or non-classification
Calcium bromide is not a sensitizer. Only 20% of the animals responded to the test material with reactions stronger than the control group. According to directive 67/548/EEC a substance should be classified as sensitizing if "a response of at least 30% of the animals is considered positive".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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