Calcium bromide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1978

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

no guideline available

GLP compliance:

no

Test type:

other: Acute Inhalation Toxicity study in Rats

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Calcium bromide

EC Number:

232-164-6

EC Name:

Calcium bromide

Cas Number:

7789-41-5

Molecular formula:

CaBr2

IUPAC Name:

calcium bromide

Details on test material:

Calcium Bromide solid, white (fine) powder

Test animals

Species:

rat

Strain:

other: Charles River CD

Sex:

male/female

Details on test animals or test system and environmental conditions:

Five male and 5 female Charles River CD rats were used in the study of the compound. The male rats weighed from 210 to 226 grams, and the females from 200 to 210 grams. The rats were housed individually in wire-mesh cages and were kept throughout the pre-and postexposure periods in a temperature and humidity controlled room i n accordance with standards outlined in the "Guide For the Care and Use of Laboratory Animals; DHEW No. (N.I.H . 74-23) 1974". Purina Laboratory Chow and water were supplied ad libitum except when the rats were in the exposure chamber.

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

not specified

Details on inhalation exposure:

During exposure, the rats were caged individually in compartmented wire-mesh exposure cages. The cages were placed i n a 160- liter cubical stainless steel and glass chamber. A constant chamber airflow was maintained by means of a rotary centrifugal air pump located at the exhaust side of the chamber. The chamber exhaust was filtered with an activated charcoal filter and a Cambridge Absolute filter before being discharged outside of the laboratory.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

ca. 1 h

Concentrations:

204 mg/l

No. of animals per sex per dose:

5

Control animals:

no

Statistics:

no further details

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

other: no effect

Effect level:

ca. 204 mg/L air (nominal)

Based on:

test mat.

Remarks on result:

other: no effect observed

Mortality:

There was no death occuring among the rats.

Clinical signs:

other: The immediate response of the rats to the experimental atmosphere was an increase of activity in preening. After 10 minutes of exposure, the rats began to settle down. There was no sign of toxicity observed during the 1-hour exposure. At the termination o

Body weight:

The body weight gain of the rats appeared to be normal throughout the 14-day observation period. All rats gained weight. The initial and final mean body weights were 212 +- 1 0 and 269 +- 36 grams, respectively.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information

Conclusions:

Inhalation exposure of rats for 1 hour to a dust atmosphere of Calcium Bromide at calculated concentration of 204 mg/l did not result in any observable toxic effects during or after the exposure.