Registration Dossier
Registration Dossier
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EC number: 232-075-2 | CAS number: 7785-21-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No data gaps were identified. The available data are adequate for risk assessment and classification and labelling purposes.
Migrated from Short description of key information:
A study was performed to assess the Contact Hypersensitivity to Diammonium phosphate in the Mouse (Local Lymph Node Assay). The GLP-study was carried out based on the guideline OECD, Section 4, Health Effects, No.429 (2010). Diammonium phosphate was found to be a non-sensitiser.
Justification for selection of skin sensitisation endpoint:
In a LLNA study according to OECD 429 diammonium phosphate was found to be not sensitising. The study is GLP-compliant and has Klimisch score 1.
Read-across justification:
Read across from diammonium phosphate to magnesium ammonium phosphate is considered justified based on following background:
The only difference between the two inorganic salts is the replacement of one ammonia ion by magnesium. Magnesium is, to the current knowledge, not known as a human skin sensitiser. As an ion with a twofold positive charge magnesium is not expected to cross the skin barrier. In addition the different solubilities of the two compounds have to be taken into account. Ammonium dihydrogenorthophosphate is highly soluble in water (400 g/l) whereas magnesium ammonium phosphate is only poorly soluble (100 mg/l). Any reaction with skin humidity would be of minor importance in comparison to ammonium dihydrogenorthophosphate. Any additional testing of magnesium ammonium phosphate would be therefore scientifically unjustified
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2007) and Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures Magnesium ammonium phosphate is not classified as skin sensitiser.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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