Registration Dossier
Registration Dossier
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EC number: 223-055-4 | CAS number: 3710-84-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-guideline study with limited details
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- Pre-guideline study
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- N,N-diethylhydroxylamine
- EC Number:
- 223-055-4
- EC Name:
- N,N-diethylhydroxylamine
- Cas Number:
- 3710-84-7
- Molecular formula:
- C4H11NO
- IUPAC Name:
- N,N-diethylhydroxylamine
- Details on test material:
- - Name of test material (as cited in study report): Diethylhydroxylamine #2697
- Analytical purity: no data
- Lot/batch No.: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: WBS/W
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1400, 2000, 2800, 4000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 190 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Oral dose(mg/kg) No.rats(dead/total) mortality time for death (hours)
1400 0/5 -
2000 2/5 -, -, -, >5, >24
2800 4/5 -, >3, >5,>24,>24
4000 5/5 >2, 5, 5, >5, >5 - Clinical signs:
- other: Muscular incoordination and general depression. Autopsy findings were negative.
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
In a pre-guideline study, groups of 5 WBS/W rats were administered dose levels of 1400, 2000, 2800, 4000 mg/kg bw of diethylhydroxylamine (undiluted) by stomach tube. The animals were then observed for 7 days following exposure. At 4000 mg/kg, 5/5 rats died, at 2800 mg/kg bw 4/5 rats died, at 2000 mg/kg bw, 2/5 rats died and at 1400 mg/kg bw none died. Clinical observations revealed muscular incoordination and general depression. Autopsy findings were negative.The LD50was 2190 mg/kg bw.
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