Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

There are no experimental studies on the toxicokinetics of propoxylated 2,2’-iminodiethanol. The toxicokinetics of the repeating unit is summarised in Illing and Barratt (2007 revised 2009). The core substance has two free hydroxy groups and a secondary amine group, thus NLP polyols are likely to consist predominantly of chains of between one and two repeating units, with some chains containing three repeating units. As the first mol of propoxylation is likely to attach to the secondary amine, the substance containing one mol of propoxylation (one repeating unit) is a structural analogue of 2,2’,2”-nitrilotriethanol. Thus the toxicokinetics of 2,2’,2”-nitrilotriethanol (outlined in Illing and Barratt, 2007 revised 2009) are also relevant.

2,2'-Iminodiethanol (CAS no 111-42-2; EINECS no 203-868-0, also known as diethanolamine) is listed in Annex 1 of Directive 67/548/EEC and in EU Regulation 1272/2008. In the Directive it was classified Xn, R22 (Harmful if swallowed), R38, R41, R48/22 and in the Regulation it is classified H302 (harmful if swallowed), H315, H318, H373. Reviews of the toxicokinetics of 2,2'-iminiodiethanol are available from the National Toxicology Program report (1999).