Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-715-5 | CAS number: 98-94-2
Carcinogenicity
Administrative data
Description of key information
Due to the lack of pre-neoplastic lesions in the 28-day study and the absence of genotoxicity in vitro and in vivo tests, DMCHA is not carcinogenic.
Key value for chemical safety assessment
Justification for classification or non-classification
Due to the lack of pre-neoplastic lesions in the 28-day study and the absence of genotoxicity in in vitro and in vivo tests, cyclohexyldimethylamine (DMCHA) is not considered likely to be carcinogenic. Therefore, DMCHA does not warrant any classification according to Directive 67/548/EEC and Regulation (EC) No 1272/2008.
Additional information
Cyclohexyldimethylamine (DMCHA) is not considered likely to be carcinogenic based on an absence of genotoxicity and relevant findings in repeated dose toxicity studies. DMCHA was administered orally to male and female Wistar rats for a minimum of 28 days at dose levels of 150 ppm, 500 and 1500 ppm. At 1500 ppm, effects consisted of decreased body weights and food consumption for males and females in the first week of treatment. This was considered to be due to palatability effect of the compound. No systemic effects were reported in the study. In a preliminary range finding study, at 5000 ppm treatment, severe reduced food consumption, body weight loss and hunched posture were reported. It is likely that these signs are related to the corrosive nature of the test substance. Since the test substance is corrosive, low dose levels are administered to the animals resulting in the absence of effects. Therefore, the primary effects will be local irritation/corrosivity. Furthermore, genotoxicity was not reported in the in vitro studies and in vivo study. This also confirms that DMCHA is not carcinogenic via genotoxic mechanisms of carcinogenesis.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
