Registration Dossier
Registration Dossier
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EC number: 305-500-5 | CAS number: 94581-02-9 Coke formed by cooling, to approximately 1500°C, hot acetylene containing split gases from aromatic residual oil produced from ethylene production by naphtha cracking at 800°C to 900°C (427°F to 482°F) (coal derived).
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Read across CAS 1333 -86 -4
The potential of Printex 70 to induce gene mutations was investigated in the Ames-test (guideline study according to OECD 471; Degussa, 1997). The plate incorporation test (experiment I) and the pre-incubation test (experiment II) were performed in Salmonella typhimurium strains TA1535, TA1537, TA98, TA100 and in E. coli strains WP2 and WP2uvrA. Printex 70 was Soxhlet extracted with toluene and the residue taken up in DMSO. The extract was tested with and without metabolic activation (S9 mix) in triplicate at the following concentrations: 100, 80, 60, 50, 40 and 10%. No cytotoxicity was observed up to the highest concentration tested. No increases in revertant frequencies were detected in any of the tester strains at any dose level either with or without metabolic activation (increases in revertant frequencies were always below a factor of 2 as compared to the controls). The positive controls were functional.
Short description of key information:
Read across CAS 1333-86-4: Ames-test (OECD 471): negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Classification is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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