Registration Dossier
Registration Dossier
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EC number: 221-375-9 | CAS number: 3081-14-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature, but the publication supported the findings from other limited studies (Bayer, 1980, Stasenkova 1970, DuPont 1992).
Data source
Reference
- Reference Type:
- publication
- Title:
- Environmental health control for the rubber industry, part II
- Author:
- McCormick, W.E.
- Year:
- 1 972
- Bibliographic source:
- Rubber Chemistry and Technology 45, 627-637
Materials and methods
- Principles of method if other than guideline:
- other: guinea pig skin sensitzing test
- GLP compliance:
- no
- Type of study:
- other: guinea pig skin sensitzing test
Test material
- Reference substance name:
- N,N'-bis(1,4-dimethylpentyl)-p-phenylenediamine
- EC Number:
- 221-375-9
- EC Name:
- N,N'-bis(1,4-dimethylpentyl)-p-phenylenediamine
- Cas Number:
- 3081-14-9
- Molecular formula:
- C20H36N2
- IUPAC Name:
- N1,N4-bis(5-methylhexan-2-yl)benzene-1,4-diamine
- Details on test material:
- Eastozone 33
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: no data
- Vehicle:
- other: no data
- Concentration / amount:
- no data
Challengeopen allclose all
- Route:
- other: no data
- Vehicle:
- other: no data
- Concentration / amount:
- no data
- No. of animals per dose:
- no data
Results and discussion
Any other information on results incl. tables
Some slight sensitizing effect to guinea pig skin was observed, no additional data available.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
