Registration Dossier
Registration Dossier
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EC number: 201-831-3 | CAS number: 88-44-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD method used
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
- Principles of method if other than guideline:
- Method: other: preliminary examination of OECD TG407
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 4-aminotoluene-3-sulphonic acid
- EC Number:
- 201-831-3
- EC Name:
- 4-aminotoluene-3-sulphonic acid
- Cas Number:
- 88-44-8
- Molecular formula:
- C7H9NO3S
- IUPAC Name:
- 2-amino-5-methylbenzene-1-sulfonic acid
- Details on test material:
- Mitsuboshi Chemical Co., Ltd.: purity >99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: sesame oil, 0.5ml/100g bw
- Doses:
- 0, 100, 250, 500, 100, 2000 mg/kg/day
- No. of animals per sex per dose:
- 4
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Any other information on results incl. tables
(See also 7.5.1 Repeated dose toxicity: oral)
PRELIMINARY EXAMINATION
4 Males and 4 females were used for the 14 days Preliminary
Examination. Any toxicological effects in the clinical
signs, body weight, food consumption, urinary findings,
hematological findings, blood chemical findings and weight
of organs was not observed in any animal at upto 2000
mg/kg/day groups.
At necropsy enlargement of cecum was observed in all animals
at 2000 mg/kg/day group.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 (and LD0) was > 2000 mg/kg.
Main toxicological effect was enlargement of cecum in both sexes at 2000 mg/kg.
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