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EC number: 201-831-3 | CAS number: 88-44-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline used
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- yes
- Remarks:
- Not limit test
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-aminotoluene-3-sulphonic acid
- EC Number:
- 201-831-3
- EC Name:
- 4-aminotoluene-3-sulphonic acid
- Cas Number:
- 88-44-8
- Molecular formula:
- C7H9NO3S
- IUPAC Name:
- 2-amino-5-methylbenzene-1-sulfonic acid
- Details on test material:
- Wako Pure Chemical Industries, Ltd.: purity >95%
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Study design
- Limit test:
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC0
- Effect conc.:
- > 10 mg/L
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 mg/L
- Basis for effect:
- growth rate
Any other information on results incl. tables
CONCENTRATIONS
nominal measured
concent- concentration (mg/L)
geometric mean
ration (mg/L) 0hr (%) 72hr (%)
0-72hr 24-48hr 24-72hr
------------------------------------------------------------
control <0.1 <0.1
<0.1 <0.1 <0.1
solvent control <0.1 <0.1
<0.1 <0.1 <0.1
10
9.6 (96) 7.9 (79)
8.5 8.5
8.5
EFFECT DATA (based on limit test)
biomass method
EbC50 (0-72hr) > 10mg/L
NOECb (0-72hr) = 10mg/L
growth rate method
ErC50 (24-48hr) > 10mg/L
NOECr (24-48hr) = 10mg/L
ErC50 (24-72hr) > 10mg/L
NOECr (24-72hr) = 10mg/L
AVERAGE CELL DENSITY DURING 72HR EXPOSURE
nominal concent- cell density (x10E4 cells/mL)
ration (mg/L) 0hr 24hr 48hr 72hr
------------------------------------------------------------
control
1.00 4.68 26.3 159
solvent control 1.00 4.73 26.3 161
10
1.00 4.79 26.3 173
AVARAGE GROWTH INHIBITION
nominal concent- biomass growth rate growth rate
ration (mg/L) (0-72hr) % (24-48hr) % (24-72hr)
%
------------------------------------------------------------
control
0
0
0
solvent control -0.7
0.7
0.1
10
-6.4
1.5
-1.6
MONITORING DATA
water temperature: 23.4-23.8°C
pH: 7.3-7.7 at start, 7.6 at end
intensity of irradiation: 4000-5000 lux
REMARK
This study was limit test at 10 mg/L only, due to author's
misunderstanding to the solubility in water. Therefore it was not a real limit test.
Applicant's summary and conclusion
- Conclusions:
- No growth inhibition was observed to green algae up to
10mg/L concentration.
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