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EC number: 270-478-5 | CAS number: 68442-22-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The test material is not acutely toxic.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 002 mg/kg bw
Additional information
Acute Oral Toxicity (FSHA 16 CFR 1500.3):
The oral LD50 was determined to be greater than 2000 mg/kg and less than 5000 mg/kg in male rats (Costello, B.A., 1983). All animals in the 5000 mg/kg group died. No death occurred at 2000 mg/kg. Sublethal effects included ruffled appearance, depression, and diarrhea. No gross abnormalities or effects on body weight were observed. No specific organ toxicity was evident. In accordance with EU CLP (Regulation (EC) No. 1272/2008), classification is not required for acute oral toxicity based on the available data.
Acute Dermal Toxicity (OECD Guideline 402):
An LD50 of > 2002 mg/kg was identified for the analog 283-392-8 via dermal application for rabbits. Prostration in one animal, and desquamation of the skin noted on test day 11 were observed. No specific organ toxicity is evident. In accordance with EU CLP (Regulation (EC) No. 1272/2008), classification is not required for acute dermal toxicity based on the available data.
Acute Inhalation Toxicity (in Accordance with OECD Guideline 403):
No data on acute inhalation toxicity is available for EC 270-478-5, but weight of evidence suggests that the test material is not toxic via inhalation route for the following reasons: 1) EC 270-478-5 has very low vapor pressure, 2) inhalation exposure is not a human relevant route of exposure, 3) acute inhalation toxicity tests were performed with the analogous substances EC 283-392-8 (LD50 > 2.3 mg/L vapor) and EC 272-723-1 (LD50 > 2.0 mg/L air). These two substances showed low acute inhalation toxicities and are not classifiable and no specific organ toxicity is evident. Taken together, EC 270-478-5 is unlikely to be acutely toxic via inhalation exposure route and no test is proposed.
Justification for classification or non-classification
In accordance with EU CLP (Regulation (EC) No. 1272/2008), classification of this substance is not required for acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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