Registration Dossier
Registration Dossier
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EC number: 202-501-1 | CAS number: 96-34-4
Endpoint summary
Administrative data
Description of key information
Key studies: Experimental studies conducted with the substance methyl chloroacetate:
LD50 oral (rat) = 107 mg/kg bw (no guideline was followed but the test method was similar to OECD 401).
LD50 dermal (rat) = 137 mg/kg bw (no guideline was followed but the test method was similar to OECD 402).
LD50 inhalation (rat) = 638 mg/m3 (OECD 403).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 107 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 638 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 137 mg/kg bw
Additional information
Acute oral toxicity: key study in rats which is considered the relevant species for acute oral toxicity classification. Although no guideline was followed, the test method was similar to OECD 401. This study is supported by two results from handbooks which have not been peer reviewed. One of these results was obtained in mice and the other result in rats. These results support the classification of the substance in the Acute toxicity Category 3 (oral).
Acute dermal toxicity: one study in rats and one study in rabbits. Both species are considered relevant for acute dermal toxicity classification. Therefore, the lowest effect level has been determined as the key study in order to be used for classification in the most severe category. The lowest dermal LD50 was observed in rats and supports the classification of substance in the Acute toxicity Category 2 (dermal).
Acute inhalation toxicity: key study in rats which is considered the relevant species for acute inhalation toxicity classification. The OECD guideline 403 was followed. This study is supported by one result obtained in mice and referenced in a handbook which has not been peer reviewed and one results obtained in rats which has been published in an article. These results support the classification of the substance in the Acute toxicity Category 2 (inhalation).
Justification for classification or non-classification
The oral LD50 was 107 mg/kg bw with a 95% confidence interval between 97.2 and 121 mg/kg bw. Therefore, the substance is classified as Acute Toxicity Category 3.
The dermal LD50 was 136.6 mg/kg bw with a 95% confidence interval between 121.3 and 153.7 mg/kg bw. Therefore, the substance is classified as Acute Toxicity Category 2.
The 4-h LC50 in rats was determined to be between 210 and 315 ppm (638 and 957 mg/m3). Therefore, the substance is classified as Acute Toxicity Category 2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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