Registration Dossier
Registration Dossier
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EC number: 202-501-1 | CAS number: 96-34-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Weight of evidence: experimental results, QSAR prediction and read-across.
Key value for chemical safety assessment
Additional information
Experimental results are available from a study conducted in Daphnia with the substance methyl chloroacetate. The EC50 for Daphnia was concluded to be 5.5 mg/l. However, no analytical monitoring was conducted during the study. Therefore, there is no evidence that the concentration of the substance was maintained during the test. A QSAR prediction conducted with the Multicase model and reported in the Danish EPA database, provides a 48 -h LC50 for methyl chloroacetate of 1.66 mg/l. The data used in the model come from an EC50 for the analogue ethyl chloroacetate which is reported in a publication with a value of 1.6 mg/l. Using the read-across approach based on the analogue ethyl chloroacetate, an EC50 value of 1.42 mg/l is calculated for methyl chloroacetate on Daphnia magna.
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