Registration Dossier
Registration Dossier
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EC number: 202-453-1 | CAS number: 95-80-7
Endpoint summary
Administrative data
Description of key information
Regarding results obtained for the mixed TDA and 2,4-TDA. It is necessary to make distinction between these two susbtances to evaluate the acute toxicity effects.
Key value for chemical safety assessment
Additional information
For 2,4 -TDA only one study, validity 2 and considered as key study, was available for skin irritation on Rabbit. No erythema and oedema were observed and substance was considered as no irritant for the skin.
Human data on local irritation/corrosion due to 2,4-TDA are not available. In Draize tests
with rabbits, the substance did not cause skin irritation and demonstrated only slight
conjunctival redness after instillation to the eye. Thus, labelling of the pure 2,4-TDA with R
36 (irritating to eye) according to current EU regulations is not appropriate.(European Union Risk Assessment Report, 28.05.2008)
Justification for classification or non-classification
Classification according to Annex I of the directive 67/548/EEC - R 36 Irritating to eyes
By CLP Cat 2A. Warning. Causes serious eye irritation.
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