Registration Dossier
Registration Dossier
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EC number: 202-453-1 | CAS number: 95-80-7
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish, juvenile growth test
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Some details are missing and no data/response relationship.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-methyl-m-phenylenediamine
- EC Number:
- 202-453-1
- EC Name:
- 4-methyl-m-phenylenediamine
- Cas Number:
- 95-80-7
- Molecular formula:
- C7H10N2
- IUPAC Name:
- 4-methylbenzene-1,3-diamine
- Details on test material:
- 2,4-diaminotoluene
ex Aldrich Chemical Co Inc, Milwaukee, WI, USA.
Purity 98%
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Twice a week during the 4 weeks study.
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Oryzias latipes
- Details on test organisms:
- Larvae (0-3 days old) used.
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 28 d
Test conditions
- Hardness:
- mean 45.8 mg/l as CaCO3
- Test temperature:
- 25 +/- 1°C
- pH:
- mean 7.88 +/- 0.18
- Dissolved oxygen:
- mean 6.8 mg/l
range 5 - 8.5 mg/l - Nominal and measured concentrations:
- Measured concentrations: mean values 0, 40.3, 68.8, 131, 263, 551
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Dose descriptor:
- NOEC
- Nominal / measured:
- meas. (arithm. mean)
- Basis for effect:
- weight
- Remarks on result:
- other: could not be determined
Any other information on results incl. tables
At the lowest tested concentration of 40.3mg/l the weight of the larvae was significantly reduced, while survival was significantly reduced at 68.8mg/l. No NOEC could be derived from this test.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
