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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Referenceopen allclose all

Reference Type:
other: Report to Research Institute for Fragrance Materials, Inc.
Title:
Unnamed
Year:
1973
Report date:
1973
Reference Type:
secondary source
Title:
Monographs on Fragrance Raw Materials: 4-tert-BUTYLCYCLOHEXANOL
Author:
Opdyke, D.L.J.
Year:
1974
Bibliographic source:
Food Cosmet Toxicol 12: 833

Materials and methods

Principles of method if other than guideline:
6 rabbits were dermally exposed to the test substance.
GLP compliance:
no
Remarks:
study performed prior to implementation of GLP

Test material

Constituent 1
Chemical structure
Reference substance name:
4-tert-butylcyclohexanol
EC Number:
202-676-4
EC Name:
4-tert-butylcyclohexanol
Cas Number:
98-52-2
Molecular formula:
C10H20O
IUPAC Name:
4-tert-butylcyclohexan-1-ol

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
6 animals (overall)
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
0/6 rabbits died during the study.
Clinical signs:
other: No clinical signs of toxicity were observed.

Applicant's summary and conclusion

Conclusions:
An acute dermal toxicity study with 4-tert-butylcyclohexanol revealed an LD50 value > 5000 mg/kg bw for rabbits. No information on test animals or test method (coverage, duration of exposure) is provided and thus, documentation is insufficient for assessment.