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Toxicological information

Carcinogenicity

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Description of key information

No evidence of carcinogenic activity in rat or mice (NTP study)

Key value for chemical safety assessment

Additional information

Under the conditions of 2-year inhalation studies in rat and mice, there was no evidence of carcinogenic activity of diethylamine in male or female F344/N rats exposed to 31, 62.5, or 125 ppm. There was also no evidence of carcinogenic activity of diethylamine in male or female B6C3F1 mice exposed to 16, 31, or 62.5 ppm (NTP 2005; Val. 2). However, the exposure to diethylamine resulted in increased incidences of nonneoplastic lesions of the nose in male and female rats and mice and of the pleura and lung in female rats.

However, under certain conditions the substance can form nitrosamines. Nitrosamines are carcinogenic in animal studies.

Justification for classification or non-classification

No need for classification according to Annex VI of Directive 67/548/EEC and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.