Registration Dossier

Administrative data

Description of key information

Irritation:
- skin: corrosive
- eye: corrosive

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Skin irritation:

In a primary skin irritation study with undiluted diethylamine, exposure times of 1, 5 and 15 min caused full thickness necrosis to the skin (BASF AG 1956; reliability score 2). Corrosive effects to skin were also found in several other valid studies (Hoechst Celanese 1989,

Union Carbide 1986/1979, Pennealt Corp. 1976, Hoechst Celanese 1989, all reliability score: 2).

 

Eye irritation:

In a primary eye irritation study in rabbits, 50 µL of the test substance were applied to the conjunctival sac of one eye (2 animals) and caused irreversible effect to the exposed eyes predominantly expressed by severe erythema, chemosis and misty-like corneal opacity with bloody discharge. Severe iritis occurred in one animal after 72 h (BASF AG, 1956; reliability score 2).

In another primary eye irritation study in rabbits, 100 µL of the test substance were applied to the conjunctival sac of one eye (2 animals) and also caused irreversible effect to the exposed eyes predominantly expressed by severe erythema, chemosis and misty-like corneal opacity with bloody discharge. As in the first study, severe iritis also occured in one animal after 72 h (Jacobs et al 1989; reliability score 2).

Several further publication confirmed these severe corrosive effects. After the application of 100 µl diethylamine, irreversible tissue necrosis appeared within minutes in portions of the conjunctivae and along the borders of the eyelids (Pennwalt 1976; reliability score 2). 50 µl undiluted test substance caused severe corneal opacity and necrosed lids (Union Carbide 1979; reliability score 2). A 1% dilution in propylene glycol applied in excess to the rabbit eye caused severe corneal damage (Union Carbide 1950; reliability score 2).


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Justification for classification or non-classification

Skin:

Due to the reported severe effects seen, diethylamine is considered as corrosive to the skin.

Eye:

Due to the reported severe corneal injury, diethylamine is considered as corrosive to the eye.

EU classification according to Annex I of Directive 67/548/EEC: C; R35

According to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 subtance is classified as Cat. 1A causes severe skin burns and eye damage.