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EC number: 203-716-3 | CAS number: 109-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
- Reference Type:
- publication
- Title:
- Comparative acute toxicity and primary irritancy of various classes of amines
- Author:
- Myers R.C., Ballantyne B.
- Year:
- 1 997
- Bibliographic source:
- Toxic Substance Mechanisms, 16:151-193
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- 2009
- Deviations:
- yes
- Remarks:
- Only females and two exposure concentrations tested
- Principles of method if other than guideline:
- - Principle of test:
A constant exposure time of 4 h was used and the concentration of test material in the chamber air was varied. The test material pumped into the top of a vertical glass evaporator tube, which was heated sufficiently to cause vapourization. Dried air was introduced through the bottom of the tube (countercurrent to the sample flow) and the resultant vapour-containing atmosphere passed to a 9-L exposure chamber. Chamber concentrations were determined by adjustment of sample and/or air flow rates. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Diethylamine
- EC Number:
- 203-716-3
- EC Name:
- Diethylamine
- Cas Number:
- 109-89-7
- Molecular formula:
- C4H11N
- IUPAC Name:
- diethylamine
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Charge No.of test material: 01067
- Identification: TK 2527
- Source: Chemicals and Plastics, South Charleston
FORM AS APPLIED IN THE TEST (if different from that of starting material): Vapour
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 9L
- The sample was metered into heated vaporizer through which a metered flow of N2 gas was maintained. The resultant vapor was then diluted with air and oxygen to produce a oxygen concentration of 20.9%
- Temperature in air chamber: 25°C - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 4000 and 8000 ppm
- No. of animals per sex per dose:
- 6 (females only)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of exposure and daily thereafter.
- Frequency of weighing: just before exposure and at sacrifice
- Necropsy of survivors performed: Yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 5 700 ppm
- 95% CL:
- 4 600 - 7 000
- Exp. duration:
- 4 h
- Remarks on result:
- other: equivalent to 17.3 mg/l air
- Mortality:
- 8000 ppm: 6/6 (3 animals within exposure, 1 animal after 2.5 h, 2 animals after 24 h).
4000 ppm: 0/6 - Clinical signs:
- other: 8000 ppm: gasping, nasal irritation, poor coordination, bloody nasal discharge, tonic convulsions. 4000 ppm: wet noses, eyes partly closed within 10 min, slight loss of coordination within 25 min.
- Body weight:
- The surviving animals gained weight.
- Gross pathology:
- Dead animals: lungs red, intestines yellow, gas and liquid filled
Survivors: no remarkable findings
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on the available study results, the test item provokes inhalative toxic effects after a 4 hour vapour exposure period in rats. The mean lethal concentration was calculated to be 17 mg/L (5700 ppm).
- Executive summary:
Acute inhalation toxicity was analyzed in a study performed with female Wistar rats. The animals were dosed with 4000 and 8000 ppm of vapourized test substance. After a 4 h exposure to 8000 ppm of the vapour all animals were dead within 24 h. No deaths occurred for the low level exposure scenario. Based on these observations a LC50 of 17.3 mg/L (5700 ppm) was calculated.
Main clinical signs observed after 8000 ppm vapour inhalation were gasping, nasal irritation, poor coordination, bloody nasal discharge and tonic convulsions.
Wet noses, partly closed eyes and a slight loss of coordination were observed for animals exposed to 4000 ppm of the vapour. At necropsy, dead rats showed gas and liquid filled red lungs and yellow intestines. Surviving rats were without remarkable finding at necropsy. Based on the estimated LC50, the test substance can be categorized for inhalative toxicity cat. 4 based on GHS criteria.
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