Registration Dossier

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented report which meets basic scientific principles.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979
Reference Type:
publication
Title:
Comparative acute toxicity and primary irritancy of various classes of amines
Author:
Myers et al.
Year:
1997
Bibliographic source:
Toxic Substance Mechanisms, 16:151-193

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): diethylamine

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
4 h
Concentrations:
4000 and 8000 ppm (nominal concentration not analytical verified).
No. of animals per sex per dose:
6 (females only)
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of exposure and daily thereafter.
- Frequency of weighing: just before exposure and at sacrifice
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LC50
Effect level:
5 700 ppm
95% CL:
4 600 - 7 000
Exp. duration:
4 h
Remarks on result:
other: equivalent to 17.3 mg/l air
Mortality:
8000 ppm: 6/6 (3 aninals within exposure, 1 animal after 2.5 h, 2 animals after 24 h).
4000 ppm: 0/6
Clinical signs:
other: 8000 ppm: gasping, nasal irritation, poor coordination, bloody nasal discharge, tonic convulsions. 4000 ppm: wet noses, eyes partly closed within 10 min, slight loss of coordination within 25 min.
Body weight:
The surviving animals gained weight.
Gross pathology:
In victims lungs red, intestines yellow, gas and liquid filled.
In survivors nothing remarkable.

Any other information on results incl. tables

Inhalation, by rats, of a metered concentration of 8000 ppm resulted in death within a few hours.

Applicant's summary and conclusion