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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Several publications about the formation of nitrosamines from nitrite and diethylamine. Publications do not meet important criteria of today standard methods.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Conditions and Chemical Reaction Mechanisms by which Nitrosamines may be Formed in biological Products with Reference to their Possible Occurrence in Food Products
Author:
Ender F. und Ceh L.
Year:
1971
Bibliographic source:
Z.Lebensmittel-Untersuch. und -Forsch. 145(3), 133-142
Reference Type:
publication
Title:
Experimental. production of nitrosamines in vivo
Author:
Galea, V. et al.
Year:
1975
Bibliographic source:
IARC Sci. Publ. 9, 121-122
Reference Type:
publication
Title:
EFFECTS OF GALLIC ACID AND OF ETHANOL ON FORMATION OF NITROSODIETHYLAMINE
Author:
Pignatelli B. et al.
Year:
1976
Bibliographic source:
IARC Sci.Publ.14, 173-178
Reference Type:
publication
Title:
Catalysis of nitrosamine synthesis
Author:
Schweinsberg F.
Year:
1974
Bibliographic source:
IARC Sci.Publ. 9, 80-85
Reference Type:
publication
Title:
Formation of N-Nitrosamines from Secondary Amines and Nitrite in Human and Animal Gastric Juice
Author:
Sen N.P. et al.
Year:
1969
Bibliographic source:
Fd.Cosmet.Toxicol. 7, 301-307
Reference Type:
publication
Title:
The Effects of Ethanol, Glucose and Sucrose on Nitrosation of Secondary Amines Following Alkalization of Reaction MiXtUTe
Author:
Yamamoto M. et al.
Year:
1979
Bibliographic source:
J.Food Hyg. Soc. 20(1), 15-20
Reference Type:
publication
Title:
Untersuchungen fiber die Entstehung cancerogener Nitrosamine im Magen
Author:
Sander J. et al.
Year:
1968
Bibliographic source:
Hoppe-Seyler's Z.Physiol.Chem. 349, 1691-1697

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline followed

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

The formation of nitrosamines from nitrite and diethylamine depends greatly on the basicity of the amines.

Applicant's summary and conclusion

Conclusions:
The formation of nitrosamines from nitrite and diethylamine depends greatly on the basicity of the amines.
Executive summary:

Nitrosamine formation in model experiments was discussed when NaNO2 is brought into reaction with alkylamines.