Registration Dossier
Registration Dossier
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EC number: 203-716-3 | CAS number: 109-89-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Several publications about the formation of nitrosamines from nitrite and diethylamine. Publications do not meet important criteria of today standard methods.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Conditions and Chemical Reaction Mechanisms by which Nitrosamines may be Formed in biological Products with Reference to their Possible Occurrence in Food Products
- Author:
- Ender F. und Ceh L.
- Year:
- 1 971
- Bibliographic source:
- Z.Lebensmittel-Untersuch. und -Forsch. 145(3), 133-142
- Reference Type:
- publication
- Title:
- Experimental. production of nitrosamines in vivo
- Author:
- Galea, V. et al.
- Year:
- 1 975
- Bibliographic source:
- IARC Sci. Publ. 9, 121-122
- Reference Type:
- publication
- Title:
- EFFECTS OF GALLIC ACID AND OF ETHANOL ON FORMATION OF NITROSODIETHYLAMINE
- Author:
- Pignatelli B. et al.
- Year:
- 1 976
- Bibliographic source:
- IARC Sci.Publ.14, 173-178
- Reference Type:
- publication
- Title:
- Catalysis of nitrosamine synthesis
- Author:
- Schweinsberg F.
- Year:
- 1 974
- Bibliographic source:
- IARC Sci.Publ. 9, 80-85
- Reference Type:
- publication
- Title:
- Formation of N-Nitrosamines from Secondary Amines and Nitrite in Human and Animal Gastric Juice
- Author:
- Sen N.P. et al.
- Year:
- 1 969
- Bibliographic source:
- Fd.Cosmet.Toxicol. 7, 301-307
- Reference Type:
- publication
- Title:
- The Effects of Ethanol, Glucose and Sucrose on Nitrosation of Secondary Amines Following Alkalization of Reaction MiXtUTe
- Author:
- Yamamoto M. et al.
- Year:
- 1 979
- Bibliographic source:
- J.Food Hyg. Soc. 20(1), 15-20
- Reference Type:
- publication
- Title:
- Untersuchungen fiber die Entstehung cancerogener Nitrosamine im Magen
- Author:
- Sander J. et al.
- Year:
- 1 968
- Bibliographic source:
- Hoppe-Seyler's Z.Physiol.Chem. 349, 1691-1697
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
Test material
- Reference substance name:
- Diethylamine
- EC Number:
- 203-716-3
- EC Name:
- Diethylamine
- Cas Number:
- 109-89-7
- Molecular formula:
- C4H11N
- IUPAC Name:
- diethylamine
Constituent 1
Results and discussion
Any other information on results incl. tables
The formation of nitrosamines from nitrite and diethylamine depends greatly on the basicity of the amines.
Applicant's summary and conclusion
- Conclusions:
- The formation of nitrosamines from nitrite and diethylamine depends greatly on the basicity of the amines.
- Executive summary:
Nitrosamine formation in model experiments was discussed when NaNO2 is brought into reaction with alkylamines.
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