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Short-term toxicity to aquatic invertebrates

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Description of key information

The test substance is acutely toxic to aquatic invertebrates.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
4.6 mg/L

Additional information

In the key study, the toxicity of diethylamine (CAS 109 -89 -7) to Ceriodaphnia dubia was assessed according to ASTM guideline (1993). The test duration was 48 hours, the test solutions were renewed daily. The test concentrations were analytically verified and deviated less than 20% from the nominal values. Nevertheless, the results are based on the mean measured test concentrations. The pH values were not adjusted and ranged from 7.6 to 8.6 throughout the test. The 48 -h LC50 was assessed to be 4.6 mg/L (95% CL: 3.1 - 6.7 mg/L, based on measured test concentrations). The 48 -h NOAEL (No-Observed-Acute Effects Level) is 3.1 mg/L (based on measured test concentrations, Arkema, 1994, report no.: 94 -6 -5329).

In addition, in an OECD 202 guideline study van Leeuwen and co-workers (1985) determined an EC50 of 56 mg/L (95% CL: 32.0 - 100 mg/L, nominal) for the mobility of Daphnia magna after a 48 -hour exposure to the test substance. This result is in accordance with additional publications which also demonstrate, that diethylamine is harmful to aquatic invertebrates. In an OECD 202 GLP study, using Daphnia magna as test species, the 48 -h EC50 was determined to be 58 mg/L (95% CL: 49.9 - 68.1 mg/L; based on measured geomean concentrations; NITE 2000). Another study, not following a specific guideline, found a nominal 48 -h EC50 of 100 mg/L for Daphnia magna and diethylamine (Bringmann & Kuehn, 1959).

Several studies with 24 -h values for Daphnia magna are available, ranging from 41 mg/L to 164 mg/L (Trenel & Kuehn, 1982, IRCHA ED, 1993 and Calamari et al., 1980). In addition, Trenel and Kuehn, 1982, observed an 24 -h EC50 of 288 mg/L when using neutralised test substance solutions were used.

The results demonstrate that the aquatic invertebrate Ceriodaphnia dubia is considerably more sensitive to diethylamine than Daphnia magna (>= factor 10).

In conclusion, diethylamine is acutely toxic to aquatic invertebrates.