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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

The test substance is acutely harmful to fish.

Key value for chemical safety assessment

Additional information

Under supervision of the Japanese Ministry of the Environment an acute fish test on Oryzias latipes according to OECD 203 was conducted and published in 1999. The 96h-LC50 was determined to be 27 mg/L. This result is supported by several further publications such as Calamari et al., 1980. Calamari et al., 1980 studied the effect of the test substance on Oncorhynchus mykiss using an Italian standard test guideline. They also investigated the effect of water hardness on the toxic effects of diethylamine. The LC50 values were determined to be 182 and 25 mg/L in hard and soft water, respectively. It is commonly accepted by European Regulatory Authorities, that within the European Union, the water hardness is rather high, therefore the LC50 determined in soft water is of low relevance for the risk assessment. The higher LC50 value is supported by several publications determining LC50 values far higher than the one published for the exposure of Oncorhynchus mykiss in soft water (ranging from 130 to > 1000 mg/L; Brooke et al., 1984; Tonogai et al., 1982; van Leeuwen et al., 1985).