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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1985-01-11 - 1985-01-30
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1985
Report date:
1985

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Pyridin-2-Ethanol
IUPAC Name:
Pyridin-2-Ethanol
Details on test material:
- Physical state: liquid
- Lot/batch No.: CH 5/1
- Stability under test conditions: Stable under the conditions of use.
- Other: Safety precautions: Routine hygienic procedures were sufficient to assure personnel health and safety.

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
7 days
Observation period (in vivo):
1-, 24-, 48- and 72 hours and 7 days after administration.
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
animal: #75 m and #76 m
Time point:
other: 24h, 48h and 72h
Score:
1.3
Max. score:
1.7
Reversibility:
not specified
Remarks on result:
other: mean score
Irritation parameter:
cornea opacity score
Basis:
animal: #77 f
Time point:
other: 24h, 48h and 72h
Score:
1.7
Max. score:
1.7
Reversibility:
not specified
Remarks on result:
other: mean score
Irritation parameter:
iris score
Basis:
animal: #75 m and #77 f
Time point:
other: 24h, 48h and 72h
Score:
1
Max. score:
1
Reversibility:
not specified
Remarks on result:
other: mean score
Irritation parameter:
iris score
Basis:
animal: #76 m
Time point:
other: 24h, 48h and 72h
Score:
0.7
Max. score:
1
Reversibility:
not specified
Remarks on result:
other: mean score
Irritation parameter:
conjunctivae score
Basis:
animal: #75 m, #76 m and #77 f
Time point:
other: 24h, 48h and 72h
Score:
2
Max. score:
2
Reversibility:
not specified
Remarks on result:
other: mean score
Irritation parameter:
chemosis score
Basis:
animal: #75 m
Time point:
other: 24h, 48h and 72h
Score:
1.3
Max. score:
1.3
Reversibility:
not specified
Remarks on result:
other: mean score
Irritation parameter:
chemosis score
Basis:
animal: #76 m, #77 f
Time point:
other: 24h, 48h and 72h
Score:
1
Max. score:
1.3
Reversibility:
not specified
Other effects:
Pyridin-2-ethanol showed a primary irritation score of 4.5 when applied to the rabbit eye mucosa.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: other: EU-GHS
Conclusions:
Under the conditions of this experiment, Pyridin-2-ethanol was found to cause a primary irritation score of 4.5 when applied to the rabbit eye mucosa. In the area of application no discoloration of the cornea and conjunctivae was observed which could be related to effects of the test article. No corrosion was observed at each of the measuring intervals.