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Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25-07-2011 - 26-07-2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Specific details on test material used for the study:
- Name of test material (as cited in study report): MOPA, 3-methoxypropylamine
- Physical state: Liquid
- Analytical urity: 99.4% by GC
- Purity test date: 12-04-2010
- Lot/batch No.: 9M603
Dissociating properties:
yes
No.:
#1
pKa:
10.4
Temp.:
20 °C
Remarks on result:
other: No details on temperature are provided, however ambient temperature is anticipated
Conclusions:
The dissociation constant of the substance was determined to be 10.4 ± 0.5 at ambient temperature.

Description of key information

The dissociation constant of the test substance was determined to be 10.4 ± 0.5 at ambient temperature, following a GLP study conducted in accordance with guideline OECD 112 using the titration method (Shajad Younis, 2011).

Key value for chemical safety assessment

pKa at 20°C:
10.4

Additional information

Although the temperature was not reported it was assumed that the study was conducted at ambient temperature.